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Google Scholar citation report
Citations : 5373
ASEAN Journal of Psychiatry received 5373 citations as per google scholar report
ASEAN Journal of Psychiatry peer review process verified at publons
| Journal Name | ASEAN Journal of Psychiatry (MyCite Report) | ||||
|---|---|---|---|---|---|
| Total Publications | 456 | ||||
| Total Citations | 5688 | ||||
| Total Non-self Citations | 12 | ||||
| Yearly Impact Factor | 0.93 | ||||
| 5-Year Impact Factor | 1.44 | ||||
| Immediacy Index | 0.1 | ||||
| Cited Half-life | 2.7 | ||||
| H-index | 30 | ||||
| Quartile |
|
- Anxiety Disorders
- Behavioural Science
- Biological Psychiatry
- Child and Adolescent Psychiatry
- Community Psychiatry
- Dementia
- Community Psychiatry
- Suicidal Behavior
- Social Psychiatry
- Psychiatry
- Psychiatry Diseases
- Psycho Trauma
- Posttraumatic Stress
- Psychiatric Symptoms
- Psychiatric Treatment
- Neurocognative Disorders (NCDs)
- Depression
- Mental Illness
- Neurological disorder
- Neurology
- Alzheimer's disease
- Parkinson's disease
Abstract
The Antipsychotic Ziprasidone has Cito-Genotoxic and Pro-Inflammatory Effects Influenced by VAL16ALA-SOD2 Gene Polymorphism
Author(s): Ivana Beatrice Mânica da Cruz, Thiago Duarte, Fernanda Barbisan, Danieli M. Pillar, Verônica Farina Azzolin, Marta Maria Medeiros Frescura DuarteObjectives: In immune cells, especially macrophages some oxidant molecules present a key role on inflammatory response trigger by pathogens and non-pathogens substances. For this reason, basal genetic superoxide-hydrogen peroxide (S-HP) imbalance as caused by Val16Ala-SOD2 single nucleotide polymorphism (SNP) could has some influence on side effects induced by pharmacological drugs. This could be de case of Ziprasidone (ZIP), a second-generation antipsychotic (SGA) used to treat some psychiatric and neurodegenerative diseases that seems to act on oxidative-inflammatory metabolism. To test this hypothesis, an in vitro study using human peripheral blood mononuclear cells (PBMCs) carrying different Val16Ala-SOD2 genotypes was performed. In standardized 72h cell cultures, the effect of ZIP exposure at plasmatic therapeutic concentration in oxidative (including level of DNA oxidation quantified by 8-deoxiguanosine) and inflammatory markers were analysed. Results showed that AA-PBMCs that have basal higher HP levels presented cito-genotoxic effect when ZIP-exposed, whereas VV-PBMCs presented higher levels of proinflammatory cytokines. The whole of results indicated some pharmacogenomic action of Val16Ala-SOD2 SNP despite in vitro methodological constrains. A
