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AMISULPRIDE AND FLUVOXAMINE COMBINATION RESULTED IN SINUS BRADYCARDIA: A CASE REPORT

Shamini Arasalingam, Mohamed Suhaib Bin Peer, Shamini Rama, Puvaneswari Jeyapalan

Abstract


Objective: Bradycardia due to the combination of amisulpride and fluvoxamine is not commonly known in the literature. Methods: We report a case of asymptomatic sinus bradycardia that occurred when amisulpride and fluvoxamine were given concurrently and resolved after cessation of both these two medications. The Naranjo scale for Adverse Drug Reaction was used to determine the likelihood of medications’ in causing bradycardia. Other possible causes were also assessed and ruled out through medical consultations. Results: This case strongly suggests that the bradycardia occurred due to the combined effect of these medications’ independent risk in causing this potentially harmful cardiac event. Conclusion: Therefore, it is important to monitor for bradycardia whenever both these medications are prescribed even at therapeutic dosages.


Keywords


Amisulpride, Fluvoxamine, Bradycardia, Adverse Drug Reaction, Drug Interaction

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